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KMID : 0363319950160010062
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Journal of Korean Oriental Internal Medicine
1995 Volume.16 No. 1 p.62 ~ p.80
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Effects of Jwagyuyeum and Woogyuyeum on Free Radical Generating Enzyme Activities and Lipid Peroxidation in Senile Rat’s Liver
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Yoon Cheol-Ho
Jung Ji-Chun
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Abstract
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Jwagyuyeum and Woogyuyeum, being known to reinforce Kidney-yin and -yang, were tested for the effects of on free-radical generating enzyme and lipid peroxidation. In vitro, levels of lipid peroxide in tissues of liver were proportionally decreased to concentration of extracts prepared from Jwagyuyeum and Woogyuyeum. They were much more decreased, when lipid peroxidation was induced with ferrous iron (Fe+2). In vivo, after both herbs were administered to the rat, levels of lipid peroxide in liver were decreased only in Jwagyuyeum. And, enzyme activities of xanthine oxidase and aldehyde oxidase in liver were not changed. It was guessed that Jwagyuyeum and Woogyuyeum inhibited lipid peroxidation directly, or acted on free radical resolving enzymes which decrease lipid peroxide. Consequently both herbs, particularly in Jwagyuyeum might delay aging.
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KEYWORD
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Jwagyuyeum, Woogyuyeum, oxygen free radical, lipid peroxide, xanthine oxidase, aldehyde oxidase, aging
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